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KMID : 0606920060140040207
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Biomolecules & Therapeutics
2006 Volume.14 No. 4 p.207 ~ p.215
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Protective Effect of Sachungwhan against CCl4- induced Hepatotoxicity
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Koo Ja-Young
Jung Ki-Hwa
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Abstract
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Sachungwhan reduced hepatotoxicity induced by carbon tetrachloride (CCl4). Improved liver function was observed by measuring the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), blood urea nitrogen (BUN), creatinine (CRE), total cholesterol (TCHO), triglyceride (TG), low density lipoprotein cholesterol (LDL-CHO), high density tipoprotein cholesterol (HDL-CHO), total protein (TP), albumin (ALB), and total bilirubin (BIL) in serum. Hepatic parameters monitored were levels of cho- lesterol (CHO), triglyceride (TG), malondialdehyde (MDA) content of cytochrome P450 (CYP), level of glu- tathione (GSH), and activities of NADPH-CYP reductase, superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx). The histopathological examination showed that the treatment of Sachungwhan relieved the ballooning degeneration of hepatocytes which had been generated by CCl4. The results suggested that hepatoprotective effects of Sachungwhan possibly are due to their promising antioxidative activity.
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KEYWORD
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Sachungwhan, CCl4, tree radical, lipid peroxidation, hepatotoxicity
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